![]() ![]() The PERSPECT, using a novel imaging protocol, can achieve comparable image quality performance in comparison with a conventional pinhole SPECT with the same configuration. Furthermore, quantitative analyses demonstrated that 3 iterations of FABCP image reconstruction (16 subsets/iteration) led to optimally reconstructed images. It was quantitatively demonstrated that for a tilt angle of 30°, comparable image qualities were obtained in terms of normalized squared error, contrast, uniformity, noise, and spatial resolution measurements, the latter at ∼0.6 mm. ![]() ![]() The sensitivity of the PERSPECT was 207 cps/MBq. Furthermore, more complex phantoms including Derenzo, Defrise, and mouse whole body were simulated and studied. Image quality was quantified as a function of different tilt angles in the acquisition and number of iterations in the reconstruction algorithm. Furthermore, a dedicated image reconstruction algorithm, finite-aperture-based circular projections (FABCP), was developed and validated for the system, enabling more accurate modeling of the system and higher quality reconstructed images. Monte Carlo (MC) and analytical simulations were utilized to accurately model and evaluate the proposed concept and design. The object to be imaged is simply placed on the desk. The system, PERSPECT, consists of an imaging desk, with a set of tilted detector and pinhole collimator placed beneath it. In the present work, we propose and assess an alternative concept for SPECT imaging enabling desktop open-gantry imaging of small animals. Given increasing efforts in biomedical research utilizing molecular imaging methods, development of dedicated high-performance small-animal SPECT systems has been growing rapidly in the last decade. ![]()
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